Novel Methods for Clinical Risk Stratification in Patients with Colorectal Liver Metastases / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 242-250, 2015.
Article
in English
| WPRIM
| ID: wpr-126955
ABSTRACT
PURPOSE:
Colorectal cancer patients with liver-confined metastases are classified as stage IV, but their prognoses can differ from metastases at other sites. In this study, we suggest a novel method for risk stratification using clinically effective factors. MATERIALS ANDMETHODS:
Data on 566 consecutive patients with colorectal liver metastasis (CLM) between 1989 and 2010 were analyzed. This analysis was based on principal component analysis (PCA).RESULTS:
The survival rate was affected by carcinoembryonic antigen (CEA) level (p < 0.001; risk ratio, 1.90), distribution of liver metastasis (p=0.014; risk ratio, 1.46), and disease-free interval (DFI; p < 0.001; risk ratio, 1.98). When patients were divided into three groups according to PCA score using significantly affected factors, they showed significantly different survival patterns (p < 0.001).CONCLUSION:
The PCA scoring system based on CEA level, distribution of liver metastasis, and DFI may be useful for preoperatively determining prognoses in order to assist in clinical decisionmaking and designing future clinical trials for CLM treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Passive Cutaneous Anaphylaxis
/
Colorectal Neoplasms
/
Carcinoembryonic Antigen
/
Odds Ratio
/
Survival Rate
/
Principal Component Analysis
/
Liver
/
Neoplasm Metastasis
Type of study:
Etiology study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2015
Type:
Article
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