Correlation between VEGF and Total WBC Count in the Synovial Fluid and Acute Phase Reactants in the Blood in Osteoarthritis / 대한정형외과연구학회지
Journal of Korean Orthopaedic Research Society
; : 100-104, 2008.
Article
in Ko
| WPRIM
| ID: wpr-126977
Responsible library:
WPRO
ABSTRACT
PURPOSE: To evaluate correlations between vascular endothelial growth factor (VEGF) which is associated with tissue remodeling and bone repair and systemic and tissue inflammation in osteoarthritis. MATERIALS AND METHODS: Sixty patients who were above grade 2 in Kellgren-Lawrence radiologic classification of osteoarthritis were classified into group 1 (grade 2, 16 patients), group 2 (grade 3, 18 patients) and group 3 (grade 4, 26 patients). All patients were checked C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and total WBC count in the blood and VEGF and total WBC count in the synovial fluid by ELISA. RESULTS: The severe in osteoarthritic change in radiographs, the more VEGF in the synovial fluid (mean value; group 1 82.7 pg/ml, group 2 111.6 pg/ml, group 3 152.6 pg/ml). VEGF in the synovial fluid were related with total WBC count in the blood and in the synovial fluid (p=0.012, p=0.028 respectively), but not related with CRP and ESR in the blood. CONCLUSION: The severe in osteoarthritic change in radiographs, the more VEGF in the synovial fluid. This facts suggested that there were much neovascularization and bone repair in the synovium of advanced osteoarthritis. Therefore further study elucidating mechanisms of tissue remodeling and its associated factors will be needed.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Osteoarthritis
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Synovial Fluid
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Synovial Membrane
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Blood Sedimentation
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C-Reactive Protein
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Acute-Phase Proteins
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Vascular Endothelial Growth Factor A
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Inflammation
Limits:
Humans
Language:
Ko
Journal:
Journal of Korean Orthopaedic Research Society
Year:
2008
Type:
Article