Correlation between VEGF and Total WBC Count in the Synovial Fluid and Acute Phase Reactants in the Blood in Osteoarthritis / 대한정형외과연구학회지
Journal of Korean Orthopaedic Research Society
;
: 100-104, 2008.
Article
in Korean
| WPRIM
| ID: wpr-126977
ABSTRACT
PURPOSE:
To evaluate correlations between vascular endothelial growth factor (VEGF) which is associated with tissue remodeling and bone repair and systemic and tissue inflammation in osteoarthritis. MATERIALS ANDMETHODS:
Sixty patients who were above grade 2 in Kellgren-Lawrence radiologic classification of osteoarthritis were classified into group 1 (grade 2, 16 patients), group 2 (grade 3, 18 patients) and group 3 (grade 4, 26 patients). All patients were checked C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and total WBC count in the blood and VEGF and total WBC count in the synovial fluid by ELISA.RESULTS:
The severe in osteoarthritic change in radiographs, the more VEGF in the synovial fluid (mean value; group 1 82.7 pg/ml, group 2 111.6 pg/ml, group 3 152.6 pg/ml). VEGF in the synovial fluid were related with total WBC count in the blood and in the synovial fluid (p=0.012, p=0.028 respectively), but not related with CRP and ESR in the blood.CONCLUSION:
The severe in osteoarthritic change in radiographs, the more VEGF in the synovial fluid. This facts suggested that there were much neovascularization and bone repair in the synovium of advanced osteoarthritis. Therefore further study elucidating mechanisms of tissue remodeling and its associated factors will be needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoarthritis
/
Synovial Fluid
/
Synovial Membrane
/
Blood Sedimentation
/
C-Reactive Protein
/
Acute-Phase Proteins
/
Vascular Endothelial Growth Factor A
/
Inflammation
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Orthopaedic Research Society
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS