Comparison of Bone Formation between Allogenic Periosteum-Derived Mesenchymal Stem Cells and Cultured Osteoblasts Transplanted into Long-Bone Defects of Rabbits / 대한정형외과연구학회지
Journal of Korean Orthopaedic Research Society
;
: 72-83, 2008.
Article
in Korean
| WPRIM
| ID: wpr-126980
ABSTRACT
PURPOSE:
To analyze the bone formation between allogenic periosteum-derived mesenchymal stem cells and cultured osteoblasts transplanted into rabbit long-bone defects. MATERIALS ANDMETHODS:
Forty white rabbits were grouped according to the material transplanted into their tibial bone defects stem cells plus agar (group 1); osteoblasts plus agar (group 2); osteoblasts plus gelfoam (group 3). Bone formation was evaluated radiologically, histologically, and using serum osteoblastic markers during 8 weeks following transplantation.RESULTS:
Group 1 and 2 both showed satisfactory bone formation, with group 2 showing thicker and more abundant bone trabeculae than group 1. Rabbits in group 3 showed worse bone formation than group 1 and 2.CONCLUSION:
These results demonstrate that rabbits implanted with osteoblasts (with agar) showed more satisfactory bone formation than those inserted with stem cells; thus osteoblasts may be useful in the treatment of bone defects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoblasts
/
Osteogenesis
/
Stem Cells
/
Transplants
/
Agar
/
Mesenchymal Stem Cells
/
Gelatin Sponge, Absorbable
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Journal of Korean Orthopaedic Research Society
Year:
2008
Type:
Article
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