A Case of Lambert-Eaton Myasthenic Syndrome with Small-Cell Lung Cancer and Transient Increase in Anti-Acetylcholine-Receptor-Binding Antibody Titer
Journal of Clinical Neurology
;
: 305-307, 2012.
Article
in English
| WPRIM
| ID: wpr-12699
ABSTRACT
BACKGROUND:
Lambert-Eaton myasthenic syndrome (LEMS) is a presynaptic neuromuscular junction disorder that is most frequently associated with small-cell lung cancer (SCLC). The titers of antibodies against voltage-gated calcium channels are frequently increased in LEMS, but only rarely is titer of anti-acetylcholine-receptor-binding antibodies (AChR-abs) increased. CASE REPORT A 57-year-old male was admitted to our hospital due to dry mouth and eyes and progressive proximal limb weakness of 2 months duration. The results of a repetitive nerve stimulation test disclosed all criteria for the electrophysiological LEMS pattern, and the patient's AChR-abs titer was 0.587 nmol/L. At a follow-up performed 5 years after successful treatment of SCLC and LEMS, his AChR-abs titer had decreased to 0.001 nmol/L.CONCLUSIONS:
We suggest that this was a case of transient pseudopositivity of AChR-abs in SCLC with LEMS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Calcium Channels
/
Lambert-Eaton Myasthenic Syndrome
/
Follow-Up Studies
/
Neuromuscular Junction Diseases
/
Extremities
/
Eye
/
Lung
/
Lung Neoplasms
/
Antibodies
/
Mouth
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2012
Type:
Article
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