A focus on extracellular Ca²⁺ entry into skeletal muscle
Experimental & Molecular Medicine
;
: e378-2017.
Article
in English
| WPRIM
| ID: wpr-127721
ABSTRACT
The main task of skeletal muscle is contraction and relaxation for body movement and posture maintenance. During contraction and relaxation, Ca²⁺ in the cytosol has a critical role in activating and deactivating a series of contractile proteins. In skeletal muscle, the cytosolic Ca²⁺ level is mainly determined by Ca²⁺ movements between the cytosol and the sarcoplasmic reticulum. The importance of Ca²⁺ entry from extracellular spaces to the cytosol has gained significant attention over the past decade. Store-operated Ca²⁺ entry with a low amplitude and relatively slow kinetics is a main extracellular Ca²⁺ entryway into skeletal muscle. Herein, recent studies on extracellular Ca²⁺ entry into skeletal muscle are reviewed along with descriptions of the proteins that are related to extracellular Ca²⁺ entry and their influences on skeletal muscle function and disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Posture
/
Relaxation
/
Sarcoplasmic Reticulum
/
Kinetics
/
Muscle, Skeletal
/
Contractile Proteins
/
Cytosol
/
Extracellular Space
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2017
Type:
Article
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