The Case Report of Malignant Lymphoma on the Submandibular Gland

ABSTRACT

PURPOSE: Extranodal marginal zone B cell lymphoma of MALT type represents approximately 8% of non- Hodgkin's lymphomas and this lymphoma is present in extranodal sites. Although the presentation of this lymphomain in stomach is usually associated with H. pylori infection in 95% of cases, MALT lymphoma found in soft tissue has been reported very rarely in the field of plastic surgery. We report a case of MALT lymphoma in the submandibular gland without any involvement of other organs such as the stomach. METHODS: A 49-year-old man complained of a huge neck mass sized about 10x12cm. It started about 2 years ago and grew rapidly for the late 6 months. It was of hard nature with erythematous skin overlying it. Under the diagnosis of possible malignant lymphoma or sarcoma, radical resection was performed and the defect was reconstructed using transverse rectus abdominis musculocutaneous free flap. RESULTS: The mass was well demarcated from the normal tissue, 11 x 10.5 x 10cm in size and whitish- gray color. Immunohistochemical analysis demonstrated that the tumor cells were LCA(+), CD20(+) , CD3(-) and CD5(-). The tumor was diagnosed as extranodal marginal zone B cell lymphoma. The patient was treated with prophylactic radiation therapy after surgery, there was no complication for 1 year. CONCLUSION: We reported that very rare form of MALT lymphoma in 49-year-old male patient was experienced with clinical characteristics, histologic features and references.