Loss of Heterozygosity of Chromosome 17p in Brain Tumors
Journal of Korean Neurosurgical Society
;
: 23-29, 1992.
Article
in Korean
| WPRIM
| ID: wpr-127937
ABSTRACT
With the methods of restriction fragment length polymorphisms(RFLPs) and southern blot analysis, gene deletion of chromosome 17p in 16 cases of brain tumors, was investigated. There were 4 cases of glioblastoma multiforme, 1 case of anaplastic astrocytoma, 4 cases of low grade astrocytoma, 3 cases of oligodendroglioma, and 4 cases of meningioma. Among restriction fragment length polymorphism(RFLP) DNA located in chromosome 17p, p144D 6 and p SNZ 22 were imployed as the probes. In eight of 16 cases(50%) constitutional heterozygosity was observe dfor p144 D6 probe on the short arm of chromosome 17, and in nine of 16 cases(56%) for PYNZ 22.1 probe. With both probes constitutional heterozygosity was observed in thirteen of 16 cases(81%). And the loss of constitutional heterozygosity was detected in two of 14 informative cases. Although, with the malignant gliomas, including 4 cases of glioblastoma multiforme and 1 case of anaplastic astrocytoma, two of 4 informative cases showed loss of constitutional heterozygosty, None of 9 informative cases showed loss of heterozygosity with the other brain tumors(low grade astrocytoma, oligodendroglioma, and meningioma).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oligodendroglioma
/
Arm
/
Astrocytoma
/
Chromosomes, Human, Pair 17
/
Polymorphism, Restriction Fragment Length
/
Brain
/
Brain Neoplasms
/
DNA
/
Blotting, Southern
/
Gene Deletion
Language:
Korean
Journal:
Journal of Korean Neurosurgical Society
Year:
1992
Type:
Article
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