Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group
Korean Journal of Pathology
;
: 1-9, 2014.
Article
in English
| WPRIM
| ID: wpr-128038
ABSTRACT
Rearrangement of anaplastic lymphoma kinase (ALK) gene is the best predictor of response to crizotinib, an ALK tyrosine kinase inhibitor. However, the prevalence of the ALK fusion is low, so accurate patient identification is crucial for successful treatment using ALK inhibitors. Furthermore, most patients with lung cancer present with advanced-stage disease at the time of diagnosis, so it is important for pathologists to detect ALK-rearranged patients while effectively maximizing small biopsy or cytology specimens. In this review, we propose a guideline recommendation for ALK testing approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Phosphotransferases
/
Biopsy
/
Protein-Tyrosine Kinases
/
Gene Rearrangement
/
Prevalence
/
Diagnosis
/
Lung
/
Lung Neoplasms
/
Lymphoma
Type of study:
Diagnostic study
/
Practice guideline
/
Prevalence study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2014
Type:
Article
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