Inhibition of IgE-mediated anaphylactic reaction by Mentha arvensis in rats / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 601-608, 2000.
Article
in Korean
| WPRIM
| ID: wpr-12806
ABSTRACT
BACKGROUND:
It has been reported that Mentha arvensis water extract (MAWE) inhibited systemic anaphylaxis and histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. OBJECTIVE ANDMETHOD:
This study was undertaken to determine the inhibitory effects of immunoglobulin E (IgE)-mediated anaphylactic reaction by MAWE. This paper deals with an evaluation of the effect of MAWE on the anti-dinitrophenyl (DNP) IgE antibody induced anaphylactic reaction in rats. We also investigated the influence of MAWE on anti-DNP IgE antibody-induced tumor necrosis factor-alpha (TNF-alpha) production.RESULTS:
MAWE inhibited passive cutaneous anaphylaxis (PCA) when intravenously, intrap- eritoneally, and orally administered. MAWE dose-dependently inhibited histamine release from RPMC activated by anti-DNP IgE antibody. Moreover, MAWE had an inhibitory effect on anti-DNP IgE antibody induced TNF-alphaproduction from RPMC.CONCLUSION:
These results suggest that MAWE inhibits the IgE-mediated anaphylactic reaction in rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunoglobulin E
/
Immunoglobulins
/
Passive Cutaneous Anaphylaxis
/
Water
/
Tumor Necrosis Factor-alpha
/
Mentha
/
Histamine Release
/
Anaphylaxis
/
Mast Cells
Limits:
Animals
Language:
Korean
Journal:
Journal of Asthma, Allergy and Clinical Immunology
Year:
2000
Type:
Article
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