Association of T Antigens with emm Genotypes of Group A Streptococci / 대한임상미생물학회지
Korean Journal of Clinical Microbiology
;
: 18-23, 2006.
Article
in Korean
| WPRIM
| ID: wpr-128147
ABSTRACT
BACKGROUND:
T typing has been used as a screening test for epidemiologic studies of group A streptococci (GAS) infections or carriers, and M typing has been performed for virulence studies. However, M typing is difficult to perform in routine laboratories. Recently, genotyping of the emm gene, which encodes the M protein, has become available. We investigated which T antigen is closely associated with a certain emmgenotype.METHODS:
GAS were collected from the children in Jinju who were asymptomatic carriers (N=349) or had acute pharyngitis (N=122) during the 3 year-period from 2002 through 2004. T typing was performed by a slide aggulutination, and emmgenotyping by PCR and DNA sequencing.RESULTS:
More than 90% of T1, T3, T6, T12, T25, and T5/27/44 antigens were associated with emm1, emm3, emm6, emm12 and 22, emm75, and emm44/61 genotypes, respectively; however, other T antigens, such as T2, T4, T7, T11, and B3264, were not associated with any particular emm genotypes.CONCLUSION:
Several T antigens are so closely associated with particular emm genotypes that one could predict emmgenotypes based on the result of T typing.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Streptococcus pyogenes
/
Virulence
/
Pharyngitis
/
Mass Screening
/
Polymerase Chain Reaction
/
Epidemiology
/
Sequence Analysis, DNA
/
Genotype
/
Antigens, Viral, Tumor
Type of study:
Screening study
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Clinical Microbiology
Year:
2006
Type:
Article
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