Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen
Journal of Veterinary Science
;
: 247-250, 2005.
Article
in English
| WPRIM
| ID: wpr-128170
ABSTRACT
Our recent study has provided that the in vitro SEC-induced proliferation of bovine T cells is preceded by a period of a non-proliferative immunoregulation of T cells that may be associated with cytokine production regulated by type 1 or type 2 T cells. Inversion of CD4+CD8+ T cell ratio and induction of CD8+T cells with immunoregulatory activity could increase the probability of intracellular survival of Staphylococcus aureus (S. aureus). The increase of activated CD8+(ACT2+ BoCD8+) T cells in cows with mastitis caused by S. aureus may be associated with immune-regulatory function in the bovine mammary gland. The difference and similarity between bovine activated CD8+ T cells (CD8+ CD26+)and well-established human CD4+ CD25+ T regulatory (Tr)cells may help to reveal their unique immune regulatory system in the host infected with S. aureus.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Staphylococcal Infections
/
Staphylococcus
/
Lymphocyte Activation
/
T-Lymphocytes
/
Superantigens
/
Cell Proliferation
/
Mastitis, Bovine
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2005
Type:
Article
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