Ketamine anaesthesia following premedication of rabbits with vitamin C
Journal of Veterinary Science
; : 239-241, 2005.
Article
in En
| WPRIM
| ID: wpr-128172
Responsible library:
WPRO
ABSTRACT
The effects of vitamin C on ketamine anesthesia was studied. In normal rabbits the onset and duration of ketamine induced anesthesia were 6.0+/-0.5 and 36.0+/-0.9 min, respectively. Pre-treatment of rabbits with 30, 60 and 240 mg/kg, i.m. of vitamin C followed by ketamine 40 mg/ kg i.m. resulted in significant (p<0.05)decrease in the onset and increase in duration of ketamine anesthesia to 5.0 +/-0.06 and 37.0+/-0.7;4.0 +/-0.5 and 39.0*0.6;2.0+/-2.3 and 44.0+/-0.8 min, respectively. There was also significant (p<0.05)decrease in the heart rates in the animals treated with vitamin C and ketamine combinations. Serum analysis showed a significant (p<0.05)increase in blood glucose. The observed decreased in serum calcium and phosphorous following ketamine injection was prevented by pretreatment with vitamin C. These results suggest that vitamin C at higher doses could potentiate ketamine anesthesia in rabbits.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Oxygen
/
Premedication
/
Ascorbic Acid
/
Respiration
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Bicarbonates
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Blood Glucose
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Body Temperature
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Calcium
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Dose-Response Relationship, Drug
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Heart Rate
Limits:
Animals
Language:
En
Journal:
Journal of Veterinary Science
Year:
2005
Type:
Article