Effect of Stress on the Expression of Rho-Kinase and Collagen in Rat Bladder Tissue
Korean Journal of Urology
;
: 132-138, 2010.
Article
in English
| WPRIM
| ID: wpr-128589
ABSTRACT
PURPOSE:
We examined the effect of stress on the pathophysiology of bladder stability in terms of enzyme levels, Rho-kinase, and bladder relaxation. MATERIALS ANDMETHODS:
A total of 48 female Sprague-Dawley rats were studied in scheduled stress environments for 7, 14, and 28 days; 24 rats were in the control group and 24 rats were in the test (stressed) group.RESULTS:
Estrogen decreased significantly whereas testosterone and dopamine increased significantly in the stress group (p<0.05). Rho-kinase was significantly increased in the rats exposed to stress stimuli for 14 days (p<0.05). Collagen types I and III in the bladder tissue were significantly higher in rats exposed to stress for 14 days and 28 days (collagen type I in the 14-day group, p<0.01; collagen type I in the 28-day group, p<0.05; collagen type III in the 14-day and 28-day groups, p<0.05). Voiding frequency increased significantly as the duration of stress exposure was prolonged, in addition to a significant decrease in volume per voiding (p<0.05).CONCLUSIONS:
The changes observed in micturition pattern, factors that contribute to smooth muscle contraction, and relaxation in the female rat bladder support the hypothesis that stress affects bladder stability.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Relaxation
/
Testosterone
/
Urination
/
Urinary Bladder
/
Dopamine
/
Collagen
/
Rats, Sprague-Dawley
/
Collagen Type I
/
Collagen Type III
/
Contracts
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Korean Journal of Urology
Year:
2010
Type:
Article
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