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A Case of Coumarin-Induced Skin Necrosis / 대한피부과학회지
Korean Journal of Dermatology ; : 1133-1135, 2000.
Article in Korean | WPRIM | ID: wpr-12877
ABSTRACT
Coumarin-induced skin necrosis is a rare complication of oral administration of coumarin derivatives. Clinically, the lesions begin with well-defined purpuric patches and progress to bullae and necrosis on the trunk, buttock or female breast. Histopathologic findings show a fibrinoid degeneration or thrombus formation in the dermal blood vessels with occasional vessel rupture and hemorrhage. We report a 77-year-old man who suffered from a typical necrotic patch on his right buttock developing during the course of coumarin therapy. Our case was diagnosed as coumarin-induced skin necrosis, based on the characteristic clinical course and histopathologic findings.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rupture / Skin / Thrombosis / Blood Vessels / Breast / Buttocks / Administration, Oral / Hemorrhage / Necrosis Limits: Aged / Female / Humans Language: Korean Journal: Korean Journal of Dermatology Year: 2000 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rupture / Skin / Thrombosis / Blood Vessels / Breast / Buttocks / Administration, Oral / Hemorrhage / Necrosis Limits: Aged / Female / Humans Language: Korean Journal: Korean Journal of Dermatology Year: 2000 Type: Article