Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection / 소아과
Korean Journal of Pediatrics
;
: 139-144, 2016.
Article
in English
| WPRIM
| ID: wpr-128899
ABSTRACT
PURPOSE:
Acute pyelonephritis (APN) is a serious bacterial infection that can cause renal scarring in children. Early identification of APN is critical to improve treatment outcomes. The neutrophil-lymphocyte ratio (NLR) is a prognostic marker of many diseases, but it has not yet been established in urinary tract infection (UTI). The aim of this study was to determine whether NLR is a useful marker to predict APN or vesicoureteral reflux (VUR).METHODS:
We retrospectively evaluated 298 pediatric patients (age≤36 months) with febrile UTI from January 2010 to December 2014. Conventional infection markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and NLR were measured.RESULTS:
WBC, CRP, ESR, and NLR were higher in APN than in lower UTI (P<0.001). Multiple logistic regression analyses showed that NLR was a predictive factor for positive dimercaptosuccinic acid (DMSA) defects (P<0.001). The area under the receiver operating characteristic (ROC) curve was high for NLR (P<0.001) as well as CRP (P<0.001) for prediction of DMSA defects. NLR showed the highest area under the ROC curve for diagnosis of VUR (P<0.001).CONCLUSION:
NLR can be used as a diagnostic marker of APN with DMSA defect, showing better results than those of conventional markers for VUR prediction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pyelonephritis
/
Bacterial Infections
/
Urinary Tract
/
Urinary Tract Infections
/
Vesico-Ureteral Reflux
/
Blood Cells
/
C-Reactive Protein
/
Logistic Models
/
Retrospective Studies
/
ROC Curve
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Humans
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2016
Type:
Article
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