Celiac Disease in South Jordan / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
;
: 222-226, 2017.
Article
in English
| WPRIM
| ID: wpr-129005
ABSTRACT
PURPOSE:
Celiac disease, an autoimmune enteropathy triggered by exposure to gluten, is not uncommon in South Jordan. However, its prevalence is underestimated due to lack of physician awareness of the diversity of disease presentation. The clinical spectrum includes classic gastrointestinal manifestations, as well as rickets, iron-deficiency anemia, short stature, elevated liver enzymes, and edema. Our goal was to evaluate celiac disease presentation in clinically diagnosed children.METHODS:
Retrospective study included all children diagnosed with celiac disease between September 2009 and September 2015. Hospital charts were reviewed. Demographic data, clinical characteristics, and follow-up were recorded.RESULTS:
Thirty-five children were diagnosed with celiac disease during the study period. Mean age±standard deviation was 6.7±3.8 years (range, 2.0–14 years). There were 17 (48.6%) female patients. The average duration between onset of symptoms and diagnosis was 16.3±18.7 months. Fifteen (42.9%) patients presented with classic malabsorption symptoms, whereas 7 (20.0%) patients presented with short stature. Positive tissue transglutaminase antibodies (tTg)-immunoglobulin A (IgA) was seen in 34 (97.1%) patients. The one patient with negative tTg-IgA had IgA deficiency. Although tTG-IgA values were not available for objective documentation of compliance, clinical data (resolution of presenting abnormalities and growth improvement) assured acceptable compliance in 22 (62.9%) patients.CONCLUSION:
CD in children may present with diverse picture. Although of the small number, the non-classical presentations are not uncommon in our rural community. Gluten-free diet is the main strategy for treatment and associated with usually correction of laboratory abnormalities and improvement of growth.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pediatrics
/
Rickets
/
Rural Population
/
Celiac Disease
/
Prevalence
/
Retrospective Studies
/
Follow-Up Studies
/
IgA Deficiency
/
Compliance
/
Anemia, Iron-Deficiency
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Pediatric Gastroenterology, Hepatology & Nutrition
Year:
2017
Type:
Article
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