Short-Term Outcome of Infliximab Therapy in Pediatric Crohn's Disease: A Single-Center Experience / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
;
: 236-243, 2017.
Article
in English
| WPRIM
| ID: wpr-129016
ABSTRACT
PURPOSE:
Studies on the efficacy of infliximab (IFX) in a large population of pediatric patients with Crohn's disease (CD) are limited, and prognostic factors are not well-known. The aim of this study was to evaluate outcomes of IFX in pediatric patients with CD and to identify factors associated with poor prognosis.METHODS:
We retrospectively analyzed medical data of 594 pediatric patients with CD between 1987 and 2013 in a tertiary center. Of these, 156 children treated with IFX were enrolled and were followed up for at least a year with intact data. Outcomes of induction and maintenance, classified as failure or clinical response, were evaluated on the tenth and 54th week of IFX therapy.RESULTS:
We treated 156 pediatric patients with CD with IFX, and the median duration of IFX therapy was 47 months. For IFX induction therapy, 134 (85.9%) patients experienced clinical response on the 10th week. Among the 134 patients who showed response to induction, 111 (82.8%) patients maintained the clinical response on the 54th week. In multivariate analysis, low hematocrit (p=0.046) at the time of IFX initiation was associated with the failure of IFX induction. For IFX maintenance therapy, longer duration from the initial diagnosis to IFX therapy (p=0.017) was associated with maintenance failure on the 54th week.CONCLUSION:
We have shown the acceptable outcomes of IFX in a large cohort of pediatric CD patients in Korea. Hematocrit and early introduction of IFX may be prognostic factors for the outcomes of IFX.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Crohn Disease
/
Multivariate Analysis
/
Retrospective Studies
/
Cohort Studies
/
Diagnosis
/
Infliximab
/
Hematocrit
/
Korea
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Pediatric Gastroenterology, Hepatology & Nutrition
Year:
2017
Type:
Article
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