Circulating Plasma and Exosomal microRNAs as Indicators of Drug-Induced Organ Injury in Rodent Models
Biomolecules & Therapeutics
;
: 367-373, 2017.
Article
in English
| WPRIM
| ID: wpr-129210
ABSTRACT
This study was performed to evaluate whether microRNAs (miRNAs) in circulating exosomes may serve as biomarkers of drug-induced liver, kidney, or muscle-injury. Quantitative PCR analyses were performed to measure the amounts of liver-specific miRNAs (miR-122, miR-192, and miR-155), kidney-specific miR-146a, or muscle-specific miR-206 in plasma and exosomes from mice treated with liver, kidney or muscle toxicants. The levels of liver-specific miRNAs in circulating plasma and exosomes were elevated in acetaminophen-induced liver injury and returned to basal levels by treatment with antioxidant N-acetyl-cysteine. Circulating miR-146a and miR-206 were increased in cisplatin-induced nephrotoxicity and bupivacaine-induced myotoxicity, respectively. Taken together, these results indicate that circulating plasma and exosomal miRNAs can be used as potential biomarkers specific for drug-induced liver, kidney or muscle injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Rodentia
/
Biomarkers
/
Polymerase Chain Reaction
/
MicroRNAs
/
Exosomes
/
Kidney
/
Liver
Limits:
Animals
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2017
Type:
Article
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