Production of Recombinant Anti-Cancer Vaccines in Plants
Biomolecules & Therapeutics
; : 345-353, 2017.
Article
in En
| WPRIM
| ID: wpr-129216
Responsible library:
WPRO
ABSTRACT
Plant expression systems have been developed to produce anti-cancer vaccines. Plants have several advantages as bioreactors for the production of subunit vaccines: they are considered safe, and may be used to produce recombinant proteins at low production cost. However, several technical issues hinder large-scale production of anti-cancer vaccines in plants. The present review covers design strategies to enhance the immunogenicity and therapeutic potency of anti-cancer vaccines, methods to increase vaccine-expressing plant biomass, and challenges facing the production of anti-cancer vaccines in plants. Specifically, the issues such as low expression levels and plant-specific glycosylation are described, along with their potential solutions.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Plants
/
Glycosylation
/
Recombinant Proteins
/
Vaccines
/
Biomass
/
Bioreactors
/
Vaccines, Subunit
Language:
En
Journal:
Biomolecules & Therapeutics
Year:
2017
Type:
Article