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Efficacy of Procarbazine, Lomustine, and Vincristine Chemotherapy for Recurrent Primary Central Nervous System Lymphomas
Brain Tumor Research and Treatment ; : 75-80, 2015.
Article in English | WPRIM | ID: wpr-12924
ABSTRACT

BACKGROUND:

Optimal treatment for recurrent primary central nervous system lymphomas (PCNSLs) has not been defined yet and there is no general consensus about the salvage chemotherapy after high-dose methotrexate (HD-MTX)-based chemotherapy. The purpose of the present study was to evaluate the efficacy and safety of procarbazine, lomustine, and vincristine (PCV) chemotherapy for recurrent PCNSLs.

METHODS:

We reviewed eight immunocompetent patients (five males/three females, mean age 56 years) who received salvage PCV chemotherapy (procarbazine 60 mg/m2, days 8 through 21 CCNU 110 mg/m2, day 1 vincristine 2 mg, days 8 and 28) for recurrent PCNSL and two patients switched to PCV chemotherapy due to severe adverse effects of HD-MTX chemotherapy. Radiologic responses, survival, and adverse effects were analyzed.

RESULTS:

Of the eight recurrent PCNSLs, three patients (37.5%) showed radiologic complete response, one patient (12.5%) showed partial response, and four patients (50%) showed progressive disease after PCV chemotherapy. Median progression free survival (PFS) from the first administration of PCV to relapse or last follow-up was 7 months (range 5-32 months) and median overall survival was 8 months (range 2-41 months). The two patients who switched to PCV chemotherapy showed PFS of 9 and 5 months from the beginning of PCV to relapse. The common side effects were thrombocytopenia, neutropenia, and peripheral neuropathy. There were 4 grade III or IV myelo-suppression, but no fatal complications, including severe hemorrhage or infection, were observed.

CONCLUSION:

Salvage PCV chemotherapy has a moderate anti-lymphoma activity for recurrent PCNSLs after the HD-MTX-based chemotherapy with tolerable toxicity.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Procarbazine / Recurrence / Thrombocytopenia / Vincristine / Central Nervous System / Methotrexate / Follow-Up Studies / Salvage Therapy / Peripheral Nervous System Diseases / Disease-Free Survival Type of study: Practice guideline / Observational study / Prognostic study Limits: Female / Humans Language: English Journal: Brain Tumor Research and Treatment Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Procarbazine / Recurrence / Thrombocytopenia / Vincristine / Central Nervous System / Methotrexate / Follow-Up Studies / Salvage Therapy / Peripheral Nervous System Diseases / Disease-Free Survival Type of study: Practice guideline / Observational study / Prognostic study Limits: Female / Humans Language: English Journal: Brain Tumor Research and Treatment Year: 2015 Type: Article