Clinical outcome of fiducial-less CyberKnife radiosurgery for stage I non-small cell lung cancer
Radiation Oncology Journal
;
: 89-97, 2015.
Article
in English
| WPRIM
| ID: wpr-129488
ABSTRACT
PURPOSE:
To evaluate the treatment results in early stage non-small cell lung cancer patients who have undergone fiducial-less CyberKnife radiosurgery (CKRS). MATERIALS ANDMETHODS:
From June 2011 to November 2013, 58 patients underwent CKRS at Asan Medical Center for stage I lung cancer. After excluding 14 patients, we retrospectively reviewed the records of the remaining 44 patients. All analyses were performed using SPSS ver. 21.RESULTS:
The median age at diagnosis was 75 years. Most patients had inoperable primary lung cancer with a poor pulmonary function test with comorbidity or old age. The clinical stage was IA in 30 patients (68.2%), IB in 14 (31.8%). The mean tumor size was 2.6 cm (range, 1.2 to 4.8 cm), and the tumor was smaller than 2 cm in 12 patients (27.3%). The radiation dose given was 48-60 Gy in 3-4 fractions. In a median follow-up of 23.1 months, local recurrence occurred in three patients (2-year local recurrence-free survival rate, 90.4%) and distant metastasis occurred in 13 patients. All patients tolerated the radiosurgery well, only two patients developing grade 3 dyspnea. The most common complications were radiation-induced fibrosis and pneumonitis. Eight patients died due to cancer progression.CONCLUSION:
The results showed that fiducial-less CKRS shows comparable local tumor control and survival rates to those of LINAC-based SABR or CKRS with a fiducial marker. Thus, fiducial-less CKRS using Xsight lung tracking system can be effectively and safely performed for patients with medically inoperable stage I non-small cell lung cancer without any risk of procedure-related complication.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Recurrence
/
Respiratory Function Tests
/
Fibrosis
/
Comorbidity
/
Survival Rate
/
Retrospective Studies
/
Follow-Up Studies
/
Radiosurgery
/
Carcinoma, Non-Small-Cell Lung
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Radiation Oncology Journal
Year:
2015
Type:
Article
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