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Virologic response to adefovir dipivoxil monotherapy is not durable in HBeAg-positive, lamivudine-resistant chronic hepatitis B patients / 대한간학회지
The Korean Journal of Hepatology ; : 52-58, 2009.
Article in Korean | WPRIM | ID: wpr-12963
ABSTRACT
BACKGROUNDS/

AIMS:

It has been shown that adefovir dipivoxil is an effective antiviral agent in the treatment of chronic hepatitis B (CHB), not only in wild-type hepatitis B virus (HBV) infection, but also in lamivudine-resistant (LAMV-R) cases. However, little is known about the durability of the virologic response to adefovir in LAMV-R CHB patients.

METHODS:

Fifteen HBV e-antigen (HBeAg)-positive, LAMV-R CHB patients showed a virologic response to adefovir monotherapy. These patients received additional adefovir for at least a further 12 months. The virologic relapse rate after discontinuation of adefovir was evaluated. In addition, predictive factors associated with virologic relapse were investigated.

RESULTS:

The median level of serum HBV DNA before adefovir administration was 7,457,840 IU/mL (range 107,920-99,524,960 IU/mL). The median duration of adefovir treatment was 30 months (range 14-46 months). During a median follow-up period of 14 months after discontinuation of adefovir, the 1-, 2-, 3-, 6-, and 12-month cumulative relapse rates were 26.7%, 53.3%, 73.3%, 80%, and 80%, respectively. High pretreatment HBV DNA levels were found to be the only factor that was predictive of off-therapy relapse.

CONCLUSIONS:

Our data suggest that the adefovir-monotherapy-induced virologic response is not durable in most patients with LAMV-R HBeAg-positive CHB, especially in those with a high pretreatment HBV DNA level.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Phosphorous Acids / Recurrence / DNA, Viral / Adenine / Retrospective Studies / Risk Factors / Lamivudine / Hepatitis B, Chronic / Drug Resistance, Viral Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: Korean Journal: The Korean Journal of Hepatology Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Phosphorous Acids / Recurrence / DNA, Viral / Adenine / Retrospective Studies / Risk Factors / Lamivudine / Hepatitis B, Chronic / Drug Resistance, Viral Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: Korean Journal: The Korean Journal of Hepatology Year: 2009 Type: Article