EGFR and KRAS Mutations in Patients With Adenocarcinoma of the Lung
The Korean Journal of Internal Medicine
;
: 48-54, 2009.
Article
in English
| WPRIM
| ID: wpr-12979
ABSTRACT
BACKGROUND/AIMS:
Mutations of the epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) are important in the pathogenesis of lung cancer, and recent reports have revealed racial and geographical differences in mutation expression.METHODS:
This study was conducted to investigate the prevalence of EGFR and KRAS mutations and their correlation with clinical variables in Korean patients with adenocarcinoma of the lung. Formalin-fixed adenocarcinoma specimens from 104 randomly selected patients diagnosed at Kosin University Gospel Hospital from October 1996 to January 2005 were used for the study.RESULTS:
We found a high prevalence of EGFR mutations and a low prevalence of KRAS mutations. EGFR mutations were present in 24% (25 of 104) of the samples one mutation in exon 18, 13 in exon 19, one in exon 20, and 10 in exon 21. The presence of an EGFR mutation was not associated with gender, smoking history, histological grade, age, bronchioalveolar components, or cancer stage in patients with adenocarcinoma of the lung.CONCLUSIONS:
Mutations of KRAS were present in 9.6% (9 of 94) of the samples eight in codon 12 and one in codon 13. EGFR mutations were never found in tumors with KRAS mutations, suggesting a mutually exclusive relationship.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
DNA, Neoplasm
/
Adenocarcinoma
/
Gene Expression Regulation, Neoplastic
/
Polymerase Chain Reaction
/
Survival Rate
/
Retrospective Studies
/
Proto-Oncogene Proteins
/
Ras Proteins
/
ErbB Receptors
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2009
Type:
Article
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