The Frequency of Serum Autoantibodies to the Epidermal Antigens among Normal Elderly People / 대한피부과학회지
Korean Journal of Dermatology
;
: 402-406, 2001.
Article
in Korean
| WPRIM
| ID: wpr-130010
ABSTRACT
BACKGROUND:
One of the age-associated changes in immunity is the increase of autoantibodies due to dysregulation of the immune function. Anti-basement membrane zone antibodies were also reported to be found in the sera taken from normal elderly people.OBJECTIVE:
The purpose of this study is to examine the frequency of autoantibodies to the epidermal antigens in the sera among normal elderly people.METHODS:
Indirect immunofluorescence using salt-split human skin and immunoblotting with extracts from epidermoid carcinoma cell line(A431) were performed using sera from forty elderly persons without any systemic disease.RESULTS:
Among 40 elderly individuals, 3 cases(7.5%) were positive for anti-basement membrane zone IgG antibodies in indirect immunofluorescence, and the titers were 110 to 140 dilution factor. In immunoblottings, 4 cases(10%) were positive with epidermal antigens; 2 were positive against the 180kD protein with IgG and IgA autoantibodies, 1 showed positive bands at 230kD and 180kD antigens with IgG, and remaining one showed positive at 130kD antigen who had negative result in indirect immunofluorescence.CONCLUSION:
Autoantibodies against epidermal antigens(bullous pemphigoid angigen[230/180kD] or pemphigus vulgaris antigen[130kD]) can be detected without any bullous cutaneous diseases among elderly people; possibly as an epiphenomenon of immunosenescence.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Autoantibodies
/
Immunoglobulin A
/
Immunoglobulin G
/
Carcinoma, Squamous Cell
/
Immunoblotting
/
Fluorescent Antibody Technique
/
Pemphigoid, Bullous
/
Pemphigus
/
Fluorescent Antibody Technique, Indirect
Limits:
Aged
/
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2001
Type:
Article
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