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Evaluation of reparative dentin formation of ProRoot MTA, Biodentine and BioAggregate using micro-CT and immunohistochemistry
Article in En | WPRIM | ID: wpr-130028
Responsible library: WPRO
ABSTRACT
OBJECTIVES: The purpose of this study was to assess the ability of two new calcium silicate-based pulp-capping materials (Biodentine and BioAggregate) to induce healing in a rat pulp injury model and to compare them with mineral trioxide aggregate (MTA). MATERIALS AND METHODS: Eighteen rats were anesthetized, cavities were prepared and the pulp was capped with either of ProRoot MTA, Biodentine, or BioAggregate. The specimens were scanned using a high-resolution micro-computed tomography (micro-CT) system and were prepared and evaluated histologically and immunohistochemically using dentin sialoprotein (DSP). RESULTS: On micro-CT analysis, the ProRoot MTA and Biodentine groups showed significantly thicker hard tissue formation (p < 0.05). On H&E staining, ProRoot MTA showed complete dentin bridge formation with normal pulpal histology. In the Biodentine and BioAggregate groups, a thick, homogeneous hard tissue barrier was observed. The ProRoot MTA specimens showed strong immunopositive reaction for DSP. CONCLUSIONS: Our results suggest that calcium silicate-based pulp-capping materials induce favorable effects on reparative processes during vital pulp therapy and that both Biodentine and BioAggregate could be considered as alternatives to ProRoot MTA.
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Full text: 1 Index: WPRIM Main subject: Immunohistochemistry / Calcium / Dentin / Pemetrexed Type of study: Prognostic_studies Limits: Animals Language: En Journal: Restorative Dentistry & Endodontics Year: 2016 Type: Article
Full text: 1 Index: WPRIM Main subject: Immunohistochemistry / Calcium / Dentin / Pemetrexed Type of study: Prognostic_studies Limits: Animals Language: En Journal: Restorative Dentistry & Endodontics Year: 2016 Type: Article