Autophagy as an Innate Immune Modulator
Immune Network
;
: 1-9, 2013.
Article
in English
| WPRIM
| ID: wpr-13004
ABSTRACT
Autophagy is a fundamental cellular process in eukaryotic cells for maintaining homeostasis by degrading cellular proteins and organelles. Recently, the roles of autophagy have been expanded to immune systems, which in turn modulate innate immune responses. More specifically, autophagy acts as a direct effector for protection against pathogens, as well as a modulator of pathogen recognition and downstream signaling in innate immune responses. In addition, autophagy controls autoimmunity and inflammatory disorders by negative regulation of immune signaling. In this review, we focus on recent advances in the role of autophagy in innate immune systems.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autophagy
/
Organelles
/
Proteins
/
Autoimmunity
/
Toll-Like Receptors
/
Eukaryotic Cells
/
Homeostasis
/
Immune System
/
Immunity, Innate
Language:
English
Journal:
Immune Network
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS