Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers
Immune Network
;
: 230-239, 2012.
Article
in English
| WPRIM
| ID: wpr-130640
ABSTRACT
Activation-induced cytidine deaminase (AID) is an enzyme that is predominantly expressed in germinal center B cells and plays a pivotal role in immunoglobulin class switch recombination and somatic hypermutation for antibody (Ab) maturation. These two genetic processes endow Abs with protective functions against a multitude of antigens (pathogens) during humoral immune responses. In B cells, AID expression is regulated at the level of either transcriptional activation on AID gene loci or post-transcriptional suppression of AID mRNA. Furthermore, AID stabilization and targeting are determined by post-translational modifications and interactions with other cellular/nuclear factors. On the other hand, aberrant expression of AID causes B cell leukemias and lymphomas, including Burkitt's lymphoma caused by c-myc/IgH translocation. AID is also ectopically expressed in T cells and non-immune cells, and triggers point mutations in relevant DNA loci, resulting in tumorigenesis. Here, I review the recent literatures on the function of AID, regulation of AID expression, stability and targeting in B cells, and AID-related tumor formation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recombination, Genetic
/
DNA
/
Immunoglobulins
/
RNA, Messenger
/
B-Lymphocytes
/
T-Lymphocytes
/
Leukemia, B-Cell
/
Transcriptional Activation
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Cell Transformation, Neoplastic
/
Protein Processing, Post-Translational
Language:
English
Journal:
Immune Network
Year:
2012
Type:
Article
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