In Vivo Non Invasive Molecular Imaging for Immune Cell Tracking in Small Animals
Immune Network
;
: 223-229, 2012.
Article
in English
| WPRIM
| ID: wpr-130642
ABSTRACT
Clinical and preclinical in vivo immune cell imaging approaches have been used to study immune cell proliferation, apoptosis and interaction at the microscopic (intra-vital imaging) and macroscopic (whole-body imaging) level by use of ex vivo or in vivo labeling method. A series of imaging techniques ranging from non-radiation based techniques such as optical imaging, MRI, and ultrasound to radiation based CT/nuclear imaging can be used for in vivo immune cell tracking. These imaging modalities highlight the intrinsic behavior of different immune cell populations in physiological context. Fluorescent, radioactive or paramagnetic probes can be used in direct labeling protocols to monitor the specific cell population. Reporter genes can also be used for genetic, indirect labeling protocols to track the fate of a given cell subpopulation in vivo. In this review, we summarized several methods dealing with dendritic cell, macrophage, and T lymphocyte specifically labeled for different macroscopic wholebody imaging techniques both for the study of their physiological function and in the context of immunotherapy to exploit imaging-derived information and immune-based treatments.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organothiophosphorus Compounds
/
Track and Field
/
Dendritic Cells
/
Lymphocytes
/
Apoptosis
/
Genes, Reporter
/
Cell Proliferation
/
Molecular Imaging
/
Cell Tracking
/
Optical Imaging
Type of study:
Practice guideline
Limits:
Animals
Language:
English
Journal:
Immune Network
Year:
2012
Type:
Article
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