Human Brain Astrocytes Mediate TRAIL-mediated Apoptosis after Treatment with IFN-gamma
Yonsei Medical Journal
;
: 354-358, 2006.
Article
in English
| WPRIM
| ID: wpr-130804
ABSTRACT
TNF-related apoptosis inducing ligand (TRAIL) expressions were studied in primary human brain astrocytes in response to pro-inflammatory cytokines. When astrocytes were treated with IL-1beta TNF-alphaor IFN-gamma TRAIL was induced in cultured fetal astrocytes. In particular, IFN-gammainduced the highest levels of TRAIL in cultured astrocytes. When astrocytes were pre-reated with IFN-gamma they induced apoptosis in TRAIL-sensitive Peer cells. Our results suggest that IFN-gamma modulates the expression of TRAIL in astrocytes, which may enhance cytotoxic sensitivity of infiltrating immune cells or brain cells other than astrocytes during inflammation of brain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Membrane Glycoproteins
/
Cells, Cultured
/
Astrocytes
/
Interferon-gamma
/
Tumor Necrosis Factor-alpha
/
Apoptosis
/
Apoptosis Regulatory Proteins
/
TNF-Related Apoptosis-Inducing Ligand
/
Antineoplastic Agents
Limits:
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
2006
Type:
Article
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