The Therapeutic Effect of Monotherapy and Combined Therapy for Androgen Blockade in Patients with Metastatic Prostate Cancer / 대한비뇨기과학회지
Korean Journal of Urology
;
: 12-16, 2003.
Article
in Korean
| WPRIM
| ID: wpr-130903
ABSTRACT
PURPOSE:
We evaluated the therapeutic effect of combined androgen blockade (CAB) compared with that of medical, or surgical, castration monotherapy, in the treatment of the metastatic prostate cancer. MATERIALS ANDMETHODS:
Of 53 patients with metastatic prostate cancer, we compared the overall survival between CAB and monotherapy groups, using a Kaplan-Meier survival curve. We also compared the therapeutic effect of flutamide and bicalutamide in the CAB group.RESULTS:
There were no differences in known prognostic factors between the CAB and monotherapy groups. The mean survival after treatment were 43 months in the CAB group, and 38 months in monotherapy group, with no significant difference (p=0.470). There were also no differences in the survival rates between the flutamide and bicalutamide groups (p=0.158).CONCLUSIONS:
These results implicate that the CAB was no better than medical, or surgical, castration monotherapy in patients with metastatic prostate cancer, and that flutamide or bicalutamide, in CAB, resulted in similar efficacies and tolerabilities.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatic Neoplasms
/
Castration
/
Survival Rate
/
Flutamide
/
Neoplasm Metastasis
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2003
Type:
Article
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