Acute Thrombosis in Coronary and Renal Arteries after Cisplatin and 5-Fluorouracil Administration
Korean Circulation Journal
;
: 410-414, 2004.
Article
in Korean
| WPRIM
| ID: wpr-131030
ABSTRACT
A 55-year old male presented with chest and abdominal pain for four hours. One day prior to admission he had received chemotherapeutic agents comprising 130 mg cisplatin and 5,200 mg 5-Fluorouracil for nasopharyngeal carcinoma. EKG showed ST elevations in the leads II, III and aVF. The levels of cardiac enzymes were elevated [creatine kinase (CK) 1129 U/L, CK-MB 180 U/L, troponin T 1.23 ng/mL and troponin I 23.29 ng/mL]. Urokinase was administered at the emergency room, but the patient's chest pain continued with persistent ST segment elevations. Urgent coronary and renal angiograms revealed thrombotic occlusive lesions in the distal right coronary and right renal arteries. Percutaneous transluminal renal angioplasty using 6.0x20 mm balloon was performed for the renal artery. However, filling defects and distal renal flow were not improved and so Abciximab (ReoPro(r)) was administered. Follow-up coronary and renal angiograms on the fifth hospital day showed no filling defects with good distal flow in both right coronary and renal arteries.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphotransferases
/
Renal Artery
/
Thorax
/
Thrombosis
/
Chest Pain
/
Urokinase-Type Plasminogen Activator
/
Abdominal Pain
/
Follow-Up Studies
/
Cisplatin
/
Angioplasty
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2004
Type:
Article
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