Evaluation of the Diagnostic Performance of Fibrin Monomer in Disseminated Intravascular Coagulation / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 143-147, 2011.
Article
in English
| WPRIM
| ID: wpr-131143
ABSTRACT
BACKGROUND:
Fibrin-related markers (FRM) such as fibrin monomer (FM) and D-dimer (DD) are considered useful biological markers for the diagnosis of disseminated intravascular coagulation (DIC). However, no studies on the diagnostic performance of different FRMs have been published in Korea. The aim of this study was to evaluate the diagnostic performance of FM for DIC in comparison with DD.METHODS:
The reference limit of FM was determined based on plasma sample data obtained from 210 control individuals. To evaluate diagnostic performance, FM data from the plasma samples of 139 patients with DIC-associated diseases were obtained for DIC scoring. FM was measured by immunoturbidimetry using STA-LIATEST FM (Diagnostica Stago, France). Patients were classified according to the DIC score as non-DIC, non-overt DIC, or overt DIC. ROC curve analyses were performed.RESULTS:
The reference limit in the control individuals was determined to be 7.80 microg/mL. Patients with DIC-associated diseases were categorized as non-DIC (N=43), non-overt DIC (N=80), and overt DIC (N=16). ROC curve analyses showed that the diagnostic performance of FM was comparable to DD in both non-overt DIC and overt DIC (P=0.596 and 0.553, respectively). In addition, FM had higher sensitivity, specificity, positive predictive value, and negative predictive value than DD for differentiating overt DIC from non-DIC.CONCLUSIONS:
This study demonstrated that the diagnostic performance of FM for DIC was comparable to DD. FM might be more sensitive and more specific than DD in the diagnosis of overt DIC, but not non-overt DIC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reagent Kits, Diagnostic
/
Reference Values
/
Fibrin Fibrinogen Degradation Products
/
Immunoassay
/
Biomarkers
/
ROC Curve
/
Area Under Curve
/
Disseminated Intravascular Coagulation
/
Nephelometry and Turbidimetry
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Laboratory Medicine
Year:
2011
Type:
Article
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