A Case of Birt-Hogg-Dube Syndrome Diagnosed by a Folliculin Gene Mutation / 대한내과학회지
Korean Journal of Medicine
;
: 102-106, 2011.
Article
in Korean
| WPRIM
| ID: wpr-131161
ABSTRACT
Birt-Hogg-Dube (BHD) syndrome is a rare, autosomal-dominant disorder that is caused by germ-line mutations in the folliculin gene. Clinically, BHD syndrome is characterized by cutaneous follicle tumors, pulmonary cysts, spontaneous pneumothorax, and an increased risk of renal cancer. A 65-year-old woman was admitted to Seoul St. Mary's Hospital to treat pneumonia, and we found that she had experienced recurrent spontaneous pneumothorax and had bilateral multiple pulmonary cysts with no history of smoking. Mutation analysis of the folliculin gene identified a novel mutation in exon 9 (c.997_998delTC; p.Ser333ArgfsX56). Except for the lung manifestation, no other features of BHD syndrome were detected in this case. Here, we report a case of BHD syndrome that manifested only as lung disease with a novel mutation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Pneumothorax
/
Smoke
/
Smoking
/
Exons
/
Gene Deletion
/
Germ-Line Mutation
/
Estrone
/
Birt-Hogg-Dube Syndrome
/
Kidney Neoplasms
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2011
Type:
Article
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