Role of Salvia miltiorrhiza for Modulation of Th2-derived Cytokines in the Resolution of Inflammation
Immune Network
;
: 288-298, 2011.
Article
in English
| WPRIM
| ID: wpr-131308
ABSTRACT
BACKGROUND:
Salvia miltiorrhiza (SM) has been used to treat inflammatory diseases including edema and arthritis; however, the anti-inflammatory mechanism of SM action remains unresolved.METHODS:
The effects of an ethanol extract of SM (ESM) on pro-inflammatory cytokines such as TNF-alpha, IL-1beta, IL-6, and NO, on anti-inflammatory cytokines including IL-4, IL-10, TGF-beta, and IL-1Ra have been studied in an attempt to elucidate the anti-inflammatory mechanism in murine macrophages.RESULTS:
ESM inhibited the production of pro-inflammatory cytokines via down-regulation of gene and protein expression whereas it increased the anti-inflammatory cytokines. Furthermore, ESM inhibited the expression of the chemokines, RANTES and CX3CL1, as well as of inflammatory mediators such as TLR-4 and 11beta-HSD1.CONCLUSION:
These results indicated that the regulatory effects of ESM may be mediated though the suppression of pro-inflammatory cytokines as well as the induction of anti-inflammatory cytokines. Consequently, we speculate that ESM has therapeutic potential for inflammation-associated disorders.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Down-Regulation
/
Cytokines
/
Transforming Growth Factor beta
/
Interleukin-4
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Interleukin-10
/
Chemokine CCL5
/
Chemokines
/
Salvia
Language:
English
Journal:
Immune Network
Year:
2011
Type:
Article
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