Effects of Xanthium stramarium and Psoralea corylifolia Extracts Combined with UVA1 Irradiation on the Cell Proliferation and TGF-beta1 Expression of Keloid Fibroblasts
Annals of Dermatology
;
: 304-309, 2013.
Article
in English
| WPRIM
| ID: wpr-131881
ABSTRACT
BACKGROUND:
Xanthium stramarium (XAS) and Psoralea corylifolia (PSC), phototoxic oriental medicinal plants, has been used in traditional medicines in Asian countries.OBJECTIVE:
The effects of highly purified XAS or PSC extract combined with ultraviolet A1 (UVA1) irradiation on cell proliferation and transforming growth factor-beta1 (TGF-beta1) expression of the keloid fibroblast were being investigated to define potential therapeutic uses for keloid treatments.METHODS:
The keloid fibroblasts were treated with XAS or PSC alone or in the combination with UVA1 irradiation. The cell viability, apoptosis, and expression of TGF-beta1 and collagen I were investigated.RESULTS:
XAS and PSC in combination with UVA1 irradiation suppressed cell proliferation and induced apoptosis of keloid fibroblasts. Furthermore, the XAS and PSC in combination with UVA1 irradiation inhibited TGF-beta1 expression and collagen synthesis in keloid fibroblasts.CONCLUSION:
These findings may open up the possibility of clinically used XAS or PSC in combination with UVA1 irradiation for keloid treatments.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Cell Survival
/
Collagen
/
Apoptosis
/
Psoralea
/
Xanthium
/
Therapeutic Uses
/
Asian People
/
Cell Proliferation
/
Transforming Growth Factor beta1
Limits:
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2013
Type:
Article
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