A Case of Adrenocortical Carcinoma with Concurrent Cushing's Syndrome and Primary Aldosteronism / 대한내분비학회지
Journal of Korean Society of Endocrinology
;
: 446-451, 2004.
Article
in Korean
| WPRIM
| ID: wpr-131900
ABSTRACT
An adrenocortical carcinoma is a rare malignancy, which is associated with a poor prognosis. Eighty percent of adrenal tumors are functional, and commonly secrete glucocorticoids alone (45%), glucocorticoids and androgens (45%) or androgen alone (10%). Less than 1% of all cases secrete aldosterone. A case of a 75 year old female patient was experienced, presenting with anadrenocortical carcinoma and associated concurrent Cushing's syndrome and primary aldosteronism. She had complained of left flank pain for 5 months, and also showed clinical features of Cushing's syndrome, hypertension, hypokalemia and a left abdominal mass. An abdominal CT* demonstrated a large left adrenal mass, with necrosis, and a hemorrhage in the left upper abdomen. The plasma renin activity was 0.51 ng/ml/hr, and the serum aldosterone level was increased by 46.4 ng/dL. A low and high dose dexamethasone suppression test revealed no suppression. Histologically, the tumor was diagnosed as a adrenocortical carcinoma. After complete removal of the mass, she received mitotan and prednisolone as adjuvant therapies. Liver and bone metastasis occurred after 6 months of treatment, so was treated with palliative radiotherapy for the bone metastasis
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Prognosis
/
Radiotherapy
/
Dexamethasone
/
Prednisolone
/
Renin
/
Adrenocortical Carcinoma
/
Cushing Syndrome
/
Flank Pain
/
Aldosterone
Type of study:
Prognostic study
Limits:
Aged
/
Female
/
Humans
Language:
Korean
Journal:
Journal of Korean Society of Endocrinology
Year:
2004
Type:
Article
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