Diabetic Ketoacidosis in a Patient with Acromegaly / 대한내분비학회지
Journal of Korean Society of Endocrinology
;
: 393-398, 2004.
Article
in Korean
| WPRIM
| ID: wpr-131916
ABSTRACT
Acromegaly is a chronic, debilitating condition caused by excessive secretion of growth hormone (GH). Impaired glucose tolerance is present in about 20-40% of acromegaly, with diabetes mellitus developing in about 10~15% of patients, but diabetic ketoacidosis is a rare association. Herein is reported a case of diabetic ketoacidosis in a 33 year-old female, with a 4 year history of typical acromegaly features. She presented with severe hyperglycemia and ketoacidosis, but with no other cause for this metabolic derangement. She had elevated plasma GH (50 ng/mL) and IGF-1 (1533 ng/mL) levels, and a pituitary macroadenoma. About 200 units of insulin per day were required for her glycemic control. However, the serum IGF-1 level and daily insulin requirement were significantly tapered after a transsphenoidal adenomectomy and long acting somatostatin analogue treatment. There was a good correlation with the daily insulin requirement and plasma IGF-1 level. This case demonstrates that severe GH excess can cause diabetic ketoacidosis, and that its successful treatment improves glucose metabolism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Acromegaly
/
Insulin Resistance
/
Insulin-Like Growth Factor I
/
Somatostatin
/
Growth Hormone
/
Diabetic Ketoacidosis
/
Diabetes Mellitus
/
Glucose
/
Hyperglycemia
Limits:
Adult
/
Female
/
Humans
Language:
Korean
Journal:
Journal of Korean Society of Endocrinology
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS