Issues in Infants with Prader-Will Syndrome: Special Review on Early Dietary Intervention and Early Use of Growth Hormone
Annals of Pediatric Endocrinology & Metabolism
; : 145-152, 2012.
Article
in En
| WPRIM
| ID: wpr-132370
Responsible library:
WPRO
ABSTRACT
Prader-Willi syndrome (PWS) is a complex multisystem genetic disorder characterized by hypothalamic-pituitary dysfunction. The main clinical features consist of neonatal hypotonia, distinctive facial features, delayed overall development with mental deficiency, behavioral abnormalities, poor growth in infancy followed by overeating with severe obesity, short stature, and hypogonadism. Recently, patients with PWS have been diagnosed at an earlier age, especially in the neonatal period. In addition, early interventions such as commencement of growth hormone therapy and dietary programs, have received attention in PWS treatment. Since early diagnosis is now possible based on both clinical symptoms and signs and on molecular genetic criteria, early dietary intervention and early growth hormone therapy during the first two years may improve neurodevelopment, increase muscle mass, and reduce obesity. Our aim in this review is to document the characteristics of infants with PWS and to provide a recent update regarding early management.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Prader-Willi Syndrome
/
Growth Hormone
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Hyperphagia
/
Early Intervention, Educational
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Early Diagnosis
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Hypogonadism
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Intellectual Disability
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Molecular Biology
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Muscle Hypotonia
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Muscles
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Humans
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Infant
Language:
En
Journal:
Annals of Pediatric Endocrinology & Metabolism
Year:
2012
Type:
Article