The Clinical Characteristics of Idiopathic Hypopituitarism in Children and Adolescents / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
;
: 58-63, 2010.
Article
in Korean
| WPRIM
| ID: wpr-132432
ABSTRACT
PURPOSE:
The purpose of this study was to evaluate the clinical evolution and endocrine features of idiopathic hypopituitarism.METHODS:
We reviewed the medical records of 33 patients with idiopathic hypopituitarism who had been followed up from 1982 to 2008, attained their adult final height, and received appropriate hormonal replacement therapy.RESULTS:
28 of these patients (85%) were male, 26 patients (79%) were delivered by breech presentation, and 18 (55%) were firstborns. The mean age at diagnosis was 10.1 +/- 4.6 years, and bone age was delayed a mean of 4.9 +/- 3.0 years. The mean standard deviation score (SDS) for height at diagnosis was -3.6 +/- 2.9. Deficiencies of pituitary hormones were observed in the following order of frequency growth hormone (100%), thyroid-stimulating hormone (97.0%), luteinizing hormone/follicle - stimulating hormone (81.8%), adrenocorticotropic hormone (45.5%), and antidiuretic hormone (12.1%). Deficiencies of 4 hormones were observed in 14 (42.4%); 3 hormones, in 11 (33.3%); 2 hormones, in 5 (18.2%); and 5 hormones, in 2 (6.1%). Spontaneous onset of puberty occurred in 6 boys (21.4%), and there were no significant differences in the clinical presentations of pituitary hormone deficiency between these boys and those with gonadotropin-releasing hormone deficiency.CONCLUSION:
Idiopathic hypopituitarism should be considered in patients of short stature who are delivered by breech presentation, and their hormone levels should be monitored periodically.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pituitary Hormones
/
Lutein
/
Breech Presentation
/
Growth Hormone
/
Thyrotropin
/
Medical Records
/
Gonadotropin-Releasing Hormone
/
Puberty
/
Adrenocorticotropic Hormone
/
Hypopituitarism
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
Korean
Journal:
Journal of Korean Society of Pediatric Endocrinology
Year:
2010
Type:
Article
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