Growth Changes after One Year of Gonadotropin-Releasing Hormone Agonist Treatment in Idiopathic True Precocious Puberty Girls: Multicenter Study in Honam Area / 대한소아내분비학회지

ABSTRACT

PURPOSE: We evaluated the effects of treatment with gonadotropin-releasing hormone agonist (GnRHa) on growth and sex hormone changes in idiopathic true precocious puberty girls. METHODS: From January 2003 through May 2007, forty-three female children, who were diagnosed as idiopathic true precocious puberty and were administered GnRHa for one year were enrolled in this retrospective study. We divided the patients into two groups according to midparental height (MPH) minus predicted adult height (PAH) (MPH-PAH > or = 5 cm, or MPH-PAH or = 5 cm), height standard deviation score for bone age (Ht SDS for BA) was significantly increased before and after treatment (-1.8 +/- 0.7 vs. -1.3 +/- 0.8). PAH after treatment was increased to 153.6 +/- 5.8 cm from 149.1 +/- 4.6 cm before treatment (PAH gain 4.5 +/- 4.4 cm). Furthermore, as MPH-PAH increased, so did PAH gain (r = 0.59, P or = 5 cm) before treatment attained significant height gain with GnRHa administration. The successful gonadal suppression was also observed.