Congenital cytomegalovirus infection: three autopsy case reports
Journal of Korean Medical Science
;
: 337-342, 2000.
Article
in English
| WPRIM
| ID: wpr-132607
ABSTRACT
We report three autopsy cases of congenital cytomegalovirus (CMV) infection in fetuses with a review of literature. The clinical manifestations in these cases of congenital CMV infection include intrauterine fetal death, hydrops fetalis, and CMV pneumonia associated with cardiovascular defect. The pathological characteristics were as follows 1) the kidney was the most frequently involved organ, followed by lung and liver, 2) CMV inclusions were found predominantly in epithelial cells and to a lesser degree in endothelial cells, 3) intrahepatic bile duct epithelial cells were frequently involved, and 4) inflammatory reaction around CMV inclusions was not prominent in the early stage of pregnancy. Diagnostic confirmation was obtained by in situ hybridization (ISH) using a biotinylated CMV-DNA probe, which demonstrated intranuclear inclusions and sometimes recognized cells that did not show intranuclear inclusion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pregnancy Complications, Infectious
/
Autopsy
/
Cytomegalovirus Infections
/
Fetal Diseases
Limits:
Female
/
Humans
/
Male
/
Pregnancy
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2000
Type:
Article
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