The Utility of Basal Serum Luteinizing Hormone Levels for Screening Central Precocious Puberty in Girls / 영남의대학술지
Yeungnam University Journal of Medicine
; : 90-94, 2013.
Article
in En
| WPRIM
| ID: wpr-133300
Responsible library:
WPRO
ABSTRACT
BACKGROUND: This study was conducted to examine if basal luteinizing hormone (LH) levels could be useful for screening central precocious puberty (CPP) in girls. METHODS: A total of 90 girls under the age of 8 years were included in this study. They underwent the gonadotropin-releasing hormone (GnRH) stimulation test at Good Gang-An Hospital from March 2008 to December 2012 for evaluation of premature sexual development. Patients were classified into two groups: the pubertal response group of patients who had 5 IU/L peak LH levels in the GnRH stimulation test, and the prepubertal response group of patients who had LH levels <5 IU/L. Chronological and bone ages, height, weight, body mass index, gonadotropin response to GnRH stimulation, and basal levels of LH, follicle-stimulating hormone, and estradiol were studied in both groups. The relationship between basal LH and peak-stimulated LH was evaluated using Spearman's correlation. To determine the optimal cut-off values of basal LH levels for differentiating between two groups, the receiver operating characteristic (ROC) curves were analyzed. RESULTS: When the correlation between basal LH levels and peak LH after GnRH stimulation was analyzed in all subjects (N=90), basal LH levels had a statistically significant positive correlation with peak stimulated LH levels (rs=0.493, p<0.001). The cut-off level of optimal basal LH was 0.1 IU/L, according to the ROC curves. Its sensitivity was 73.3%, and its specificity was 77.8%. CONCLUSION: The study results showed that serum basal LH levels are useful for screening CPP in girls.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Puberty, Precocious
/
Lutein
/
Body Weight
/
Luteinizing Hormone
/
Mass Screening
/
ROC Curve
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Gonadotropin-Releasing Hormone
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Sexual Development
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Estradiol
/
Follicle Stimulating Hormone
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Yeungnam University Journal of Medicine
Year:
2013
Type:
Article