Carotid artery intima media thickness in obese children: relation with cardiovascular risk factors / 소아과
Korean Journal of Pediatrics
;
: 1091-1096, 2007.
Article
in Korean
| WPRIM
| ID: wpr-133341
ABSTRACT
PURPOSE:
The of common carotid artery intima media thickness (IMT) is an acknowledged noninvasive marker for early atherosclerotic changes. We investigate whether common carotid IMT is different between obese and normal-weight children and also evaluate the relationships IMT with cardiovascular risk factors.METHODS:
We collected the clinical data (age, sex, pubertal stage, body mass index) and measured blood pressure, glucose, insulin, lipid profiles and adiponectin in 49 obese children (mean age, 12 years) and 24 nonobese children as controls. The control group was composed of 24 nonobese children of the same age, sex and pubertal stage. We measured the carotid IMT of all subjects by B-mode ultrasound with a 7.5-MHz linear transducer and analyzed.RESULTS:
Obese children demonstrated a significantly thicker intima media (mean, 0.34 mm, peak, 0.42 mm) compared to the control group (mean, 0.31 mm, peak, 0.38 mm, P<0.01). IMT was significantly correlated to the BMI (r=0.431, P<0.01), age (r=0.317, P<0.01), total cholesterol (r=0.377, P<0.01), triglyceride (r=0.253, P<0.05) and low-density lipoprotein cholesterol (r=0.289, P<0.05). Serum adiponectin was significantly lower in obese children than in controls (11.2 ng/mL vs. 14.7 ng/mL, P<0.05) and negatively related with IMT (r=-0.267, P<0.05).CONCLUSION:
Obesity is associated with increased carotid artery IMT in children. Our results suggest vascular changes in obesity seem to occur already in childhood and vascular ultrasonography may helpful for screening cardiovascular complications in obese children.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transducers
/
Triglycerides
/
Blood Pressure
/
Carotid Arteries
/
Mass Screening
/
Cholesterol
/
Risk Factors
/
Ultrasonography
/
Carotid Artery, Common
/
Adiponectin
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2007
Type:
Article
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