Effect of Oral Supplementation with Branched-chain Amino Acid (BCAA) during Radiotherapy in Patients with Hepatocellular Carcinoma: A Double-Blind Randomized Study / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 24-31, 2011.
Article
in English
| WPRIM
| ID: wpr-133439
ABSTRACT
PURPOSE:
The present study evaluated whether oral supplementation with a branched-chain amino acid (BCAA) improves the biochemical and amino acid profiles of liver tumor patients undergoing radiotherapy. MATERIALS ANDMETHODS:
Patients were randomly assigned to one of 2 groups a group given oral supplementation with BCAA granules (LIVACT granules; Samil Pharm Co., Korea, each granule containing L-isoleucine 952 mg, L-leucine 1,904 mg, and L-valine 1,144 mg) during radiotherapy, or a placebo group. Physical and biochemical examinations and measurements, including subjective symptoms, Child-Pugh class, body mass index, plasma albumin concentration, and plasma amino acid profiles were monitored.RESULTS:
Fifty were enrolled between November 2005 and November 2006. We also analyzed data from 37 hepatocellular carcinoma (HCC) patients in order to evaluate a more homogenous group. The two groups of patients were comparable in terms of age, gender, Child-Pugh score, and underlying hepatitis virus type. Serum albumin, total protein, liver enzymes, and cholesterol showed a tendency to increase in the BCAA group. In this group, the percentage of cases that reverted to normal serum albumin levels between 3 and 10 weeks after administration of BCAA was significantly higher (41.18%) than in the placebo group (p=0.043).CONCLUSION:
Oral supplementation with a BCAA preparation seems to help HCC patients undergoing radiotherapy by increasing the BCAA concentration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxytetracycline
/
Plasma
/
Valine
/
Serum Albumin
/
Body Mass Index
/
Cholesterol
/
Carcinoma, Hepatocellular
/
Amino Acids, Branched-Chain
/
Hepatitis Viruses
/
Isoleucine
Type of study:
Controlled clinical trial
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Cancer Research and Treatment
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS