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Otologic Manifestation in IgG4-Related Systemic Disease
Clinical and Experimental Otorhinolaryngology ; : 52-54, 2011.
Article in English | WPRIM | ID: wpr-133447
ABSTRACT
IgG4-related systemic disease, including autoimmune pancreatitis, is a multi-organ disorder characterized by elevated serum immunoglobulin G4 (IgG4) concentration and IgG4-positive plasma cell infiltration. We report a case of a 66-year-old woman with IgG4-related hearing disorder, presenting with fluctuating mixed hearing loss with middle ear effusion. The serum IgG4 level was elevated and pathological examination revealed dense infiltration of IgG4-positive lymphocyte in the renal parenchyma, lung tissue and lacrimal gland. With intravenous methylprednisolone at a dose of 60 mg daily, improvement of hearing loss were observed. No recurrence was observed for 6 months with mainternance of prednisolone and methotrexate.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancreatitis / Plasma Cells / Recurrence / Autoimmune Diseases / Otitis Media with Effusion / Immunoglobulin G / Immunoglobulins / Methylprednisolone / Prednisolone / Lymphocytes Limits: Aged / Female / Humans Language: English Journal: Clinical and Experimental Otorhinolaryngology Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancreatitis / Plasma Cells / Recurrence / Autoimmune Diseases / Otitis Media with Effusion / Immunoglobulin G / Immunoglobulins / Methylprednisolone / Prednisolone / Lymphocytes Limits: Aged / Female / Humans Language: English Journal: Clinical and Experimental Otorhinolaryngology Year: 2011 Type: Article