Otologic Manifestation in IgG4-Related Systemic Disease
Clinical and Experimental Otorhinolaryngology
;
: 52-54, 2011.
Article
in English
| WPRIM
| ID: wpr-133447
ABSTRACT
IgG4-related systemic disease, including autoimmune pancreatitis, is a multi-organ disorder characterized by elevated serum immunoglobulin G4 (IgG4) concentration and IgG4-positive plasma cell infiltration. We report a case of a 66-year-old woman with IgG4-related hearing disorder, presenting with fluctuating mixed hearing loss with middle ear effusion. The serum IgG4 level was elevated and pathological examination revealed dense infiltration of IgG4-positive lymphocyte in the renal parenchyma, lung tissue and lacrimal gland. With intravenous methylprednisolone at a dose of 60 mg daily, improvement of hearing loss were observed. No recurrence was observed for 6 months with mainternance of prednisolone and methotrexate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatitis
/
Plasma Cells
/
Recurrence
/
Autoimmune Diseases
/
Otitis Media with Effusion
/
Immunoglobulin G
/
Immunoglobulins
/
Methylprednisolone
/
Prednisolone
/
Lymphocytes
Limits:
Aged
/
Female
/
Humans
Language:
English
Journal:
Clinical and Experimental Otorhinolaryngology
Year:
2011
Type:
Article
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