Does blastomere biopsy in preimplantation genetic diagnosis affect early serum beta-hCG levels? / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
;
: 31-36, 2011.
Article
in English
| WPRIM
| ID: wpr-133475
ABSTRACT
OBJECTIVE:
To determine whether the serum beta-human chorionic gonadotropin (hCG) profile following preimplantation genetic diagnosis (PGD) is lower than that of intracytoplasmic sperm injection (ICSI) cycles.METHODS:
A total of 129 PGD cycles and 1,161 age-matched ICSI cycles, which resulted in pregnancy (serum beta-hCG> or =5 mIU/mL) on post-ovulation day (POD) 12 were included. We compared the mean serum beta-hCG levels on POD 12, 14, 21, and 28, doubling time of serum hCG, and created a cut-off value for predicting a singleton pregnancy in each group.RESULTS:
The mean serum beta-hCG concentration of the PGD group was significantly lower than that of the control group on POD 12, 14, and 21. The doubling time of serum beta-hCG at each time interval showed no significant difference. The cut-off-value of serum beta-hCG for predicting a single viable pregnancy was 32.5 mIU/mL on POD 12 and 113.5 mIU/mL on POD 14 for the PGD group, which was lower than that for the control group.CONCLUSION:
Blastomere biopsy may decrease the beta-hCG-producing activity of the trophoblasts, especially in early pregnancy. Setting a lower cut-off value of serum beta-hCG for predicting pregnancy outcomes in PGD may be needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostaglandins D
/
Trophoblasts
/
Biopsy
/
Blastomeres
/
Pregnancy Outcome
/
Preimplantation Diagnosis
/
Sperm Injections, Intracytoplasmic
/
Chorionic Gonadotropin
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Clinical and Experimental Reproductive Medicine
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS