Treadmill Exercise Improves Memory Function Depending on Circadian Rhythm Changes in Mice / 대한배뇨장애요실금학회지
International Neurourology Journal
;
: S141-S149, 2016.
Article
in English
| WPRIM
| ID: wpr-134026
ABSTRACT
PURPOSE:
Exercise enhances memory function by increasing neurogenesis in the hippocampus, and circadian rhythms modulate synaptic plasticity in the hippocampus. The circadian rhythm-dependent effects of treadmill exercise on memory function in relation with neurogenesis were investigated using mice.METHODS:
The step-down avoidance test was used to evaluate short-term memory, the 8-arm maze test was used to test spatial learning ability, and 5-bromo-2’-deoxyuridine immunofluorescence was used to assess neurogenesis. Western blotting was also performed to assess levels of synaptic plasticity-associated proteins, such as brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element-binding protein, early growth response protein 1, postsynaptic density protein 95, and growth-associated protein 43. The mice in the treadmill exercise at zeitgeber 1 group started exercising 1 hour after sunrise, the mice in the treadmill exercise at zeitgeber 6 group started exercising 6 hours after sunrise, and the mice in the treadmill exercise at zeitgeber 13 group started exercising 1 hour after sunset. The mice in the exercise groups were forced to run on a motorized treadmill for 30 minutes once a day for 7 weeks.RESULTS:
Treadmill exercise improved short-term memory and spatial learning ability, and increased hippocampal neurogenesis and the expression of synaptic plasticity-associated proteins. These effects of treadmill exercise were stronger in mice that exercised during the day or in the evening than in mice that exercised at dawn.CONCLUSIONS:
Treadmill exercise improved memory function by increasing neurogenesis and the expression of synaptic plasticity-associated proteins. These results suggest that the memory-enhancing effect of treadmill exercise may depend on circadian rhythm changes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein-Tyrosine Kinases
/
Blotting, Western
/
Fluorescent Antibody Technique
/
Circadian Rhythm
/
Cyclic AMP Response Element-Binding Protein
/
Brain-Derived Neurotrophic Factor
/
GAP-43 Protein
/
Early Growth Response Protein 1
/
Exercise Test
/
Neurogenesis
Limits:
Animals
Language:
English
Journal:
International Neurourology Journal
Year:
2016
Type:
Article
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