Decreased Serum Brain-Derived Neurotrophic Factor Levels in Elderly Korean with Dementia
Psychiatry Investigation
;
: 299-305, 2009.
Article
in English
| WPRIM
| ID: wpr-134175
ABSTRACT
OBJECTIVE:
The primary purpose of this study was to investigate the differences in the serum brain-derived neurotrophic factor (BDNF) level between elderly Korean people over 65 years with and without dementia.METHODS:
171 individuals over 65 years were enrolled in this study. Screening for cognitive impairments was carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). One hundred thirty-two subjects scored below 1.5 standard deviations (SD) of the mean MMSE-KC score, and these were evaluated using the Consortium to Establish a Registry for Alzheimer's Disease, Korean version (CERAD-K) and the Geriatric Depression Scale (GDS). The Clinical Dementia Rating Scale (CDRS) and the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) diagnostic criteria were used for further evaluation. Subjects with a CDRS score of 1 or higher were classified as having Alzheimer's disease (AD), and subjects with a CDRS score of 0.5 were classified as having a mild cognitive impairment (MCI). Subjects with a CDRS score of 0 were classified as having aging-associated cognitive decline (AACD). Serum BDNF levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) method.RESULTS:
The serum BDNF levels were significantly lower in the subjects with MCI and AD compared with the healthy controls (p<0.01). A significant correlation was found between the total MMSE-KC score and serum BDNF level (r=0.295; p<0.01). However, no significant correlation was observed between the severity of MMSE-KC and the total GDS score. A significant difference was found in the total score of GDS between the AACD group and subjects with AD (p<0.05).CONCLUSION:
This study suggested that BDNF might be involved in the pathophysiology of cognitive decline in elderly people.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Enzyme-Linked Immunosorbent Assay
/
Mass Screening
/
Brain-Derived Neurotrophic Factor
/
Dementia
/
Diagnostic and Statistical Manual of Mental Disorders
/
Deoxycytidine
/
Depression
/
Alzheimer Disease
/
Cognitive Dysfunction
Type of study:
Practice guideline
/
Prognostic study
/
Screening study
Limits:
Aged
/
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2009
Type:
Article
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