Lipoprotein(a) Level and Influential Factors in Children with Common Renal Diseases
Journal of the Korean Society of Pediatric Nephrology
; : 125-132, 2003.
Article
in Ko
| WPRIM
| ID: wpr-134315
Responsible library:
WPRO
ABSTRACT
PURPOSE: Lipoprotein(a) is a genetically determined risk factor for atherosclerotic vascular disease and is elevated in patients with renal disease. Especially the patients with nephrotic syndrome exhibit excessively high Lp(a) plasma concentrations. Also the patients with end- stage renal disease have elevated Lp(a) levels. But the mechanism underlying this elevation is unclear. Thus, in this study, by measuring the level of serum Lp(a) in common renal diseases in children, we hoped to see whether there would be a change in Lp(a) in renal diseases other than nephrotic syndrome. Then, we figured out its implications, and looked for the factors that affect the Lp(a) concentrations. METHODS: A total of 75 patients(34 patients with hematuria of unknown etiology, 10 with hematuria and hypercalciuria, 8 with IgA nephropathy, 8 with poststreptococcal glomerulonephritis, 3 with Henoch-Schonlein nephritis, 7 with urinary tract infection, and 5 with orthostatic proteinuria) were studied. The control group included 20 patients without renal and liver disease. Serum Lp(a), total protein, and albumin levels, 24-hour urine protein and calcium excretions, creatinine clearance and the number of RBCs and WBCs in the urinary sediment were evaluated. Data analysis was performed using the Student t-test and a P-value less than 0.05 was considered to be statistically significant. RESULTS: Lp(a) was not correlated with 24-hour urine calcium and creatinine. Lp(a) level had a positive correlation with proteinuria and negative correlation with serum albumin and serum protein. Among the common renal diseases in children, Lp(a) was elevated only in orthostatic proteinuria(P<0.05). CONCLUSION: Lp(a) is correlated with proteinuria, serum protein, and serum albumin, but not with any kind of specific renal disease. Afterward, Lp(a) needs to be assessed in patients with orthostatic proteinuria and its possible role as a prognostic factor could be confirmed.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Plasma
/
Proteinuria
/
Urinary Tract Infections
/
Vascular Diseases
/
Serum Albumin
/
Calcium
/
Risk Factors
/
Statistics as Topic
/
Lipoprotein(a)
/
Creatinine
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Humans
Language:
Ko
Journal:
Journal of the Korean Society of Pediatric Nephrology
Year:
2003
Type:
Article