Pulmonary Adenocarcinoma with Heterotopic Ossification
Journal of Korean Medical Science
;
: 504-510, 2009.
Article
in English
| WPRIM
| ID: wpr-134336
ABSTRACT
Pulmonary adenocarcinoma is a common malignancy that often involves calcification; however, bone formation in primary lung adenocarcinoma is extremely rare. In ten cases of primary pulmonary adenocarcinoma with heterotopic ossification, we detected immunoreactivity against TGF-beta1, osteopontin, osteocalcin and Runx2 in the fibroblastic stroma and tumor cells within the area of ossification. Our results suggest that in primary pulmonary adenocarcinoma, heterotopic ossification occurs via intramembranous bone formation. To our knowledge, only 11 other cases of pulmonary adenocarcinoma with heterotopic ossification have been reported. Here, we present ten cases of pulmonary adenocarcinoma showing heterotopic ossification with a description of previously published results and the histogenesis of heterotopic bone formation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Adenocarcinoma
/
Tomography, X-Ray Computed
/
Osteocalcin
/
Ossification, Heterotopic
/
Core Binding Factor Alpha 1 Subunit
/
Osteopontin
/
Transforming Growth Factor beta1
/
Lung Neoplasms
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2009
Type:
Article
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